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QUICK ANSWER
"Yes" is an interjection which is often translated as "sí", and "that's true" is a phrase which is often translated as "eso es cierto". Learn more about the difference between "yes" and "that's true" below.
yes(
yehs
)An adverb is a word that describes a verb, an adjective, or other adverbs (e.g., to run quickly, very tired).
An interjection is a short utterance that expresses emotion, hesitation, or protest (e.g., Wow!).
A noun is a word referring to a person, animal, place, thing, feeling, or idea (e.g., man, dog, house).
that's true(
thahts
tru
)A phrase is a group of words commonly used together (e.g., once upon a time).
1. (general)
a. eso es cierto
Parking downtown can be pretty tricky. - That's true. Maybe we should just take the train in.Estacionar en el centro puede ser muy complicado. - Eso es cierto. Quizá debemos ir con el tren nomás.
b. eso es verdad
The store closes at 8:00. - That's true. I don't think we'll get there in time.La tienda cierra a las 8:00. - Eso es verdad. No creo que lleguemos a tiempo.